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This module helps to select targets that share sequence similarity with microbial proteins known to interact with host (human). The sequence information for host pathogen interacting proteins is obtained from online databases such as HPIDB (version 2.0), PHIbase (version 4.2) and PHISTO (version 2). Sequence similarity is computed by BLAST algorithm.
References:
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Ammari MG, Gresham CR, McCarthy FM, Nanduri B.(2016) HPIDB 2.0: a curated database for host–pathogen interactions. -
Urban M, Pant R, Raghunath A, Irvine AG, Pedro H and Hammond-Kosack K (2015): The Pathogen-Host Interactions database: additions and future developments -
Saliha Durmuş Tekir, Tunahan Çakır, Emre Ardıç, Ali Semih Sayılırbaş, Gökhan Konuk, Mithat Konuk, Hasret Sarıyer, Azat Uğurlu, İlknur Karadeniz, Arzucan Özgür, Fatih Erdoğan Sevilgen and Kutlu Ö. Ülgen (2013): PHISTO: pathogen–host interaction search tool
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